Clinical features and genetic spectrum in Chinese patients with recessive hereditary spastic paraplegia

Although many causative genes of hereditary spastic paraplegia (HSP) have been uncovered in recent years, there are still approximately 50% of HSP patients without genetically diagnosis, especially in autosomal recessive (AR) HSP patients. Rare studies have been performed to determine the genetic spectrum and clinical profiles of recessive HSP patients in the Chinese population. In this study, we investigated 24 Chinese index AR/sporadic...