HIF1α‐induced upregulation of KLF4 promotes migration of human vascular smooth muscle cells under hypoxia

Hypoxia‐induced vascular smooth muscle cells (VSMCs) migration plays an important role in vascular remodeling and is implicated in vascular diseases, such as atherosclerosis and pulmonary hypertension. We previously observed the increased expression of krüppel‐like factor 4 (KLF4) in VSMCs under hypoxia. However, whether the upregulation of KLF4 participates in hypoxia‐induced VSMCs migration is still unknown. In this study, we demonstrated that...