CD200 dysfunction in neuron contributes to synaptic deficits and cognitive impairment

Neuronal CD200 plays critical role in neuron-microglia communication and negatively related to pathological development of Alzheimer's disease, but its contribution retroacts to synaptic function is still not clear. Here, we directly injected adeno-associated virus into hippocampus of APP/PS1 mice to induce neuron-specific CD200 overexpression; subsequently, we detected cognition function, synaptic function, and the microglial responses during...