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Impact of comorbidities and functional impairment on 5-year loss of health utility in patients with lower-limb osteoarthritis in the KHOALA cohort

Published on Nov 1, 2019in Quality of Life Research2.488
· DOI :10.1007/s11136-019-02243-4
A.Y. Omorou3
Estimated H-index: 3
(University of Lorraine),
H. Achit (University of Lorraine)+ 4 AuthorsFrancis Guillemin33
Estimated H-index: 33
(University of Lorraine)
Abstract
Purpose To examine the respective and combined impact of “hypothetical” functional impairment (FI) and burden of comorbidities accrual on a 5-year risk of health utility (HU) loss in osteoarthritis (OA).
  • References (22)
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We propose an approach to conduct mediation analysis for survival data with time-varying exposures, mediators, and confounders. We identify certain interventional direct and indirect effects through a survival mediational g-formula and describe the required assumptions. We also provide a feasible parametric approach along with an algorithm and software to estimate these effects. We apply this method to analyze the Framingham Heart Study data to investigate the causal mechanism of smoking on mort...
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#1Behnam Sharif (U of C: University of Calgary)H-Index: 7
#2Rochelle E. Garner (Statistics Canada)H-Index: 14
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Summary Objective To estimate and project the productivity costs of work loss (PCWL) associated with osteoarthritis (OA) in Canada using the Population Health Model (POHEM). Design We integrated an employment module based on 2006 Canadian Census into the previously developed microsimulation model of OA. The Canadian Community Health Survey (CCHS) Cycle 2.1 with an OA sample aged 25–64 ( n = 7067) was used to calibrate the results of the employment module and to estimate the fraction of non-emplo...
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#1Jean-Hugues Salmon (URCA: University of Reims Champagne-Ardenne)H-Index: 3
#2Anne-Christine Rat (Paris V: Paris Descartes University)H-Index: 18
Last. Bruno Fautrel (UPMC: Pierre-and-Marie-Curie University)H-Index: 25
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Objective An overview of the economic consequences – overall costs as well as cost breakdown (direct and indirect) – of hip and knee osteoarthritis (OA) worldwide. Methods A systematic literature search of EMBASE, MEDLINE, Scopus and Cochrane databases for articles was performed independently by two rheumatologists who used the same predefined eligible criteria. Papers without abstracts and in languages other than English or French were excluded. Extracted costs were converted to an annual cost ...
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#2Jacek A. Kopec (UBC: University of British Columbia)H-Index: 50
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Summary Objectives To estimate the future direct cost of OA in Canada using a population-based health microsimulation model of osteoarthritis (POHEM-OA). Methods We used administrative health data from the province of British Columbia (BC), Canada, a survey of a random sample of BC residents diagnosed with OA (Ministry of Health of BC data), Canadian Institute of Health Information (CIHI) cost data and literature estimates to populate a microsimulation model. Cost components associated with phar...
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#1Nienke E Lankhorst (EUR: Erasmus University Rotterdam)H-Index: 6
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Summary Objective To examine the proportion of isolated patellofemoral osteoarthritis (PFOA) compared to tibiofemoral osteoarthritis (TFOA) in middle-aged participants with early osteoarthritis (OA) symptoms of the knee; to describe the natural course of PFOA compared with that of TFOA and to identify whether patients with PFOA have a different phenotype compared to patients with TFOA, or with combined PFOA and TFOA (combined osteoarthritis (COA)). Design Participants with early OA symptoms of t...
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Imagine an oncologist knocks on your door with the following problem: she wants to know how much she could reduce mortality among her bone marrow transplant patients by prescribing a new drug that prevents graft-versus-host disease, a side effect of allogeneic marrow transplantation.1 While graft-versus-host disease is associated in observational studies with an increased risk of mortality, it also reduces the risk of leukemia relapse – thus, any drug that prevents graft-versus-host disease may ...
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#1Francis GuilleminH-Index: 58
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OBJECTIVES: This study aimed to describe the prevalence of symptomatic knee and hip osteoarthritis (OA) and its course over time, as well as identify prognostic factors of OA course and determinants of costs and access to care in France in a patient cohort. METHODS: Subjects aged 40 to 75 years, with uni- or bilateral symptomatic hip and/or knee OA (ACR criteria), Kellgren and Lawrence (KL) stage 2 or greater, were recruited from a French national prevalence survey for the multicenter KHOALA coh...
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#1Kossar Hosseini (Paris V: Paris Descartes University)H-Index: 3
#2Cécile Gaujoux-Viala (UPMC: Pierre-and-Marie-Curie University)H-Index: 15
Last. Francis Guillemin (Paris V: Paris Descartes University)H-Index: 33
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Introduction Co-morbidities can influence generic measurement of health indirect utility. We investigated their impact to assess indirect utility with the Medical Outcomes Study Short Form 6D (SF-6D) in patients with osteoarthritis (OA). Methods In patients with hip and knee OA from the Knee and Hip Osteo-Arthritis Long-term Assessment (KHOALA) study, co-morbidities were assessed by the Functional Co-morbidity Index. Multivariate linear regressions were used to determine predictors of utility sc...
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#1Francis Guillemin (Nancy-Université)H-Index: 58
#2Anne-Christine RatH-Index: 18
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Summary Objective Osteoarthritis (OA) epidemiologic data are scarce in Europe. To estimate the prevalence of symptomatic knee and hip OA in a multiregional sample in France. Design A two-phase population-based survey was conducted in six regions in 2007–2009. On initial phone contact using random-digit dialing, subjects 40–75 years old were screened with a validated questionnaire. Subjects screened positive were invited for ascertainment: physical examination and hip and/or knee radiography (Kel...
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