Loss of MafA and MafB expression promotes islet inflammation
Abstract
Maf transcription factors are critical regulators of beta-cell function. We have previously shown that reduced MafA expression in human and mouse islets is associated with a pro-inflammatory gene signature. Here, we investigate if the loss of Maf transcription factors induced autoimmune processes in the pancreas. Transcriptomics analysis showed expression of pro-inflammatory as well as immune cell marker genes. However, clusters of CD4+ T and...
Paper Details
Title
Loss of MafA and MafB expression promotes islet inflammation
Published Date
Jun 24, 2019
Journal
Volume
9
Issue
1
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