Abstract 2415: Polygenic risk-tailored screening for prostate cancer: A cost-effectiveness analysis

Background Screening for prostate cancer with prostate specific antigen (PSA) remains controversial. Risk-tailoring based on age and polygenic profile might conserve the benefits of PSA screening whilst reducing overdiagnosis. This study evaluates the cost-effectiveness and benefit-to-harm balance of polygenic risk-tailored screening for prostate cancer. Methods A life-table approach was used. A hypothetical cohort of 4.48 million men in England...