An anionic human protein mediates cationic liposome delivery of genome editing proteins into mammalian cells
Abstract
Delivery into mammalian cells remains a significant challenge for many applications of proteins as research tools and therapeutics. We recently reported that the fusion of cargo proteins to a supernegatively charged (–30)GFP enhances encapsulation by cationic lipids and delivery into mammalian cells. To discover polyanionic proteins with optimal delivery properties, we evaluate negatively charged natural human proteins for their ability to...
Paper Details
Title
An anionic human protein mediates cationic liposome delivery of genome editing proteins into mammalian cells
Published Date
Jul 2, 2019
Journal
Volume
10
Issue
1
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