Replication fork stalling elicits chromatin compaction for the stability of stalling replication forks

Significance Stalling replication forks require strict cellular regulations for their stability. The intra-S phase checkpoint has been demonstrated essential for preventing stalling/stalled replication forks from collapse. In this study, a cellular pathway was uncovered that regulates the stabilization of stalling replication forks. We found that, when replication forks stall, the chromatin surrounding stalling forks becomes compacted. The fork...