Genomic Correlates of Disease Progression and Treatment Response in Prospectively Characterized Gliomas

The genomic landscape of gliomas has been characterized and now contributes to disease classification, yet the relationship between molecular profile and disease progression and treatment response remain poorly understood.Experimental Design: We integrated prospective clinical sequencing of 1,004 primary and recurrent tumors from 923 glioma patients with clinical and treatment phenotypes.Thirteen percent of glioma patients harbored a pathogenic...