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Genetic therapies, human genetic enhancement, and … eugenics?

Published on Jul 4, 2019in Gene Therapy 3.20
· DOI :10.1038/s41434-019-0088-1
  • References (3)
  • Citations (0)
Published on Aug 1, 2017in Nature 41.58
Hong Ma27
Estimated H-index: 27
(Oregon National Primate Research Center),
Nuria Marti-Gutierrez1
Estimated H-index: 1
(OHSU: Oregon Health & Science University)
+ 28 AuthorsRiffat Ahmed10
Estimated H-index: 10
(OHSU: Oregon Health & Science University)
CRISPR–Cas9 genome editing is used to induce a DNA repair response and correct a disease-causing heterozygous mutation in human embryos with reduced mosaicism and preferential repair using the wild-type copy of the gene.
259 Citations Source Cite
Published on Jan 25, 2017in Science Translational Medicine 16.71
Waseem Qasim26
Estimated H-index: 26
(UCL: University College London),
Hong Zhan7
Estimated H-index: 7
(UCL: University College London)
+ 22 AuthorsK Somana1
Estimated H-index: 1
(GOSH: Great Ormond Street Hospital)
Autologous T cells engineered to express chimeric antigen receptor against the B cell antigen CD19 (CAR19) are achieving marked leukemic remissions in early-phase trials but can be difficult to manufacture, especially in infants or heavily treated patients. We generated universal CAR19 (UCART19) T cells by lentiviral transduction of non–human leukocyte antigen–matched donor cells and simultaneous transcription activator-like effector nuclease (TALEN)–mediated gene editing of T cell receptor α ch...
184 Citations Source Cite
Published on Mar 6, 2014in The New England Journal of Medicine 79.26
Pablo Tebas54
Estimated H-index: 54
David Stein4
Estimated H-index: 4
+ 17 AuthorsGeoff Nichol1
Estimated H-index: 1
Background CCR5 is the major coreceptor for human immunodeficiency virus (HIV). We investigated whether site-specific modification of the gene (“gene editing”) — in this case, the infusion of autologous CD4 T cells in which the CCR5 gene was rendered permanently dysfunctional by a zinc-finger nuclease (ZFN) — is safe. Methods We enrolled 12 patients in an open-label, nonrandomized, uncontrolled study of a single dose of ZFN-modified autologous CD4 T cells. The patients had chronic aviremic HIV i...
736 Citations Source Cite
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