Ammonia inhibits energy metabolism in astrocytes in a rapid and glutamate dehydrogenase 2-dependent manner

Pages: 683763
Published: Jun 27, 2019
Abstract
null Hepatic encephalopathy (HE) is a severe neuropsychiatric syndrome frequently observed in patients with liver disease or portosystemic shunt. In HE, astrocyte dysfunction is a primary factor impairing neuronal activity under hyperammonemia. Here we show that mitochondria in human- and rat-derived cellular HE models undergo fragmentation within hours under hyperammonemia in a reversible manner. Moreover, mitochondrial respiration as well as...
Paper Details
Title
Ammonia inhibits energy metabolism in astrocytes in a rapid and glutamate dehydrogenase 2-dependent manner
Published Date
Jun 27, 2019
Journal
Pages
683763
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