Streptolysin production and activity is central to in vivo pathotype and disease outcome in GAS infections

Pages: 686303
Published: Jun 28, 2019
Abstract
Streptococcus pyogenes (GAS) is among the most diverse of all human pathogens, responsible for a range of clinical manifestations, from mild superficial infections such as pharyngitis to serious invasive infections such as necrotising fasciitis and sepsis. The drivers of these different disease phenotypes are not known. The GAS cholesterol-dependent cytolysin, streptolysin O (SLO), has well established cell and tissue destructive activity. We...
Paper Details
Title
Streptolysin production and activity is central to in vivo pathotype and disease outcome in GAS infections
Published Date
Jun 28, 2019
Journal
Pages
686303
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