Abstract 4669: Overcoming therapy resistance in stem cell-rich triple negative breast cancer through p38 MAP kinase inhibition

Background: Patients with triple-negative breast cancers (TNBCs) develop chemotherapeutic resistance and have a high mortality rate. Classification of TNBCs based on molecular profiling has enabled the identification of one subtype that is particularly enriched for cancer stem cells (CSCs) and genes involved in epithelial-mesenchymal transition (EMT) pathways. The EMT pathways, as well as CSCs, have been independently associated with...