Abstract 3967: Comparison of neoadjuvant FOLFIRINOX alone vs FOLFIRINOX + stereotactic body radiation as immune-modulators of the pancreatic adenocarcinoma microenvironment

Pancreatic ductal adenocarcinoma (PDAC) has dismal five-year survival (<9%). We examined the impact of neoadjuvant FOLFIRINOX alone or in combination with stereotactic body radiation (SBRT) on biomarkers in the PDAC tumor microenvironment (TME). We hypothesize conventional therapies may unmask novel targets in the TME that can be leveraged to enhance the efficacy of immunotherapy in PDAC. We conducted a pilot study using FFPE-tumor...