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Yesterday’s Child: How Gene Editing for Enhancement Will Produce Obsolescence—and Why It Matters

Published on Jul 3, 2019in American Journal of Bioethics 4.85
· DOI :10.1080/15265161.2019.1618943
Abstract
  • References (30)
  • Citations (13)
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References30
Newest
Published on Sep 1, 2017in Nature Medicine 32.62
David Scott83
Estimated H-index: 83
,
Feng Zhang104
Estimated H-index: 104
Analysis of the ExAC and 1000 Genomes data sets estimates the impact of inter-individual variation on the efficacy and safety of therapies based on CRISPR endonucleases.
27 Citations Source Cite
Published on Aug 1, 2017in American Journal of Human Genetics 8.86
Kelly E. Ormond28
Estimated H-index: 28
(Stanford University),
Douglas P. Mortlock20
Estimated H-index: 20
(Vandy: Vanderbilt University)
+ 11 AuthorsAnna Middleton16
Estimated H-index: 16
With CRISPR/Cas9 and other genome-editing technologies, successful somatic and germline genome editing are becoming feasible. To respond, an American Society of Human Genetics (ASHG) workgroup developed this position statement, which was approved by the ASHG Board in March 2017. The workgroup included representatives from the UK Association of Genetic Nurses and Counsellors, Canadian Association of Genetic Counsellors, International Genetic Epidemiology Society, and US National Society of Geneti...
34 Citations Source Cite
Published on Aug 1, 2017in Nature 41.58
Hong Ma27
Estimated H-index: 27
(Oregon National Primate Research Center),
Nuria Marti-Gutierrez1
Estimated H-index: 1
(OHSU: Oregon Health & Science University)
+ 28 AuthorsRiffat Ahmed10
Estimated H-index: 10
(OHSU: Oregon Health & Science University)
CRISPR–Cas9 genome editing is used to induce a DNA repair response and correct a disease-causing heterozygous mutation in human embryos with reduced mosaicism and preferential repair using the wild-type copy of the gene.
259 Citations Source Cite
Published on Dec 1, 2016in Immunity & Ageing 4.02
Giuseppe Passarino46
Estimated H-index: 46
(University of Calabria),
Francesco De Rango13
Estimated H-index: 13
(University of Calabria),
Alberto Montesanto19
Estimated H-index: 19
(University of Calabria)
Healthy aging and longevity in humans are modulated by a lucky combination of genetic and non-genetic factors. Family studies demonstrated that about 25 % of the variation in human longevity is due to genetic factors. The search for genetic and molecular basis of aging has led to the identification of genes correlated with the maintenance of the cell and of its basic metabolism as the main genetic factors affecting the individual variation of the aging phenotype. In addition, studies on calorie ...
42 Citations Source Cite
Published on Dec 2, 2015in American Journal of Bioethics 4.85
John Collins Harvey49
Estimated H-index: 49
(University of Manchester)
Two genetic technologies capable of making heritable changes to the human genome have revived interest in, and in some quarters a very familiar panic concerning, so-called germline interventions. These technologies are: most recently the use of CRISPR/Cas9 to edit genes in non-viable IVF zygotes and Mitochondrial Replacement Therapy (MRT) the use of which was approved in principle in a landmark vote earlier this year by the United Kingdom Parliament. The possibility of using either of these tech...
21 Citations Source Cite
Published on Dec 2, 2015in American Journal of Bioethics 4.85
Sarah Chan10
Estimated H-index: 10
,
Peter J. Donovan39
Estimated H-index: 39
(UCI: University of California, Irvine)
+ 5 AuthorsAlan Regenberg8
Estimated H-index: 8
(Johns Hopkins University)
16 Citations Source Cite
Published on Aug 1, 2015in Trends in Molecular Medicine 11.02
Tetsuya Ishii11
Estimated H-index: 11
(Hokkaido University)
Genetically modifying eggs, sperm, and zygotes (‘germline' modification) can impact on the entire body of the resulting individual and on subsequent generations. With the advent of genome-editing technology, human germline gene modification is no longer theoretical. Owing to increasing concerns about human germline gene modification, a voluntary moratorium on human genome-editing research and/or the clinical application of human germline genome editing has recently been called for. However, whet...
31 Citations Source Cite
Published on Jul 2, 2015in The New England Journal of Medicine 79.26
Eric S. Lander245
Estimated H-index: 245
Genome editing holds great therapeutic promise, but its application in humans would require not only overcoming serious technical challenges but also addressing serious risks and fraught ethical issues.
51 Citations Source Cite
Published on Jul 1, 2015in Protein & Cell 6.23
Julian Savulescu45
Estimated H-index: 45
(University of Oxford),
Jonathan Pugh6
Estimated H-index: 6
(University of Oxford)
+ 1 AuthorsChristopher Gyngell5
Estimated H-index: 5
(University of Oxford)
The publication of the first study to use gene editing techniques in human embryos (Liang et al., 2015) has drawn outrage from many in the scientific community. The prestigious scientific journals Nature and Science have published commentaries which call for this research to be strongly discouraged or halted all together (Lanphier et al., 2015; Baltimore et al., 2015). We believe this should be questioned. There is a moral imperative to continue this research.
31 Citations Source Cite
Published on May 1, 2015in Protein & Cell 6.23
Puping Liang7
Estimated H-index: 7
(SYSU: Sun Yat-sen University),
Yanwen Xu14
Estimated H-index: 14
(SYSU: Sun Yat-sen University)
+ 13 AuthorsYujing Li10
Estimated H-index: 10
(SYSU: Sun Yat-sen University)
Genome editing tools such as the clustered regularly interspaced short palindromic repeat (CRISPR)-associated system (Cas) have been widely used to modify genes in model systems including animal zygotes and human cells, and hold tremendous promise for both basic research and clinical applications. To date, a serious knowledge gap remains in our understanding of DNA repair mechanisms in human early embryos, and in the efficiency and potential off-target effects of using technologies such as CRISP...
458 Citations Source Cite
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Published on Jul 3, 2019in American Journal of Bioethics 4.85
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Published on Jul 3, 2019in American Journal of Bioethics 4.85
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Published on Jul 3, 2019in American Journal of Bioethics 4.85
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Published on Jul 3, 2019in American Journal of Bioethics 4.85
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Published on Jul 3, 2019in American Journal of Bioethics 4.85
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Published on Jul 3, 2019in American Journal of Bioethics 4.85
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