Differential toxic effects of bile acid mixtures in isolated mitochondria and physiologically relevant HepaRG cells
Abstract
Bile acids (BAs) are recognised as the causative agents of toxicity in drug-induced cholestasis (DIC). Research in isolated mitochondria and HepG2 cells have demonstrated BA-mediated mitochondrial dysfunction as a key mechanism of toxicity in DIC. However, HepG2 cells are of limited suitability for DIC studies as they do not express the necessary physiological characteristics. In this study, the mitotoxic potentials of BA mixtures were assessed...
Paper Details
Title
Differential toxic effects of bile acid mixtures in isolated mitochondria and physiologically relevant HepaRG cells
Published Date
Dec 1, 2019
Journal
Volume
61
Pages
104595 - 104595
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