CDetection: CRISPR-Cas12b-based DNA detection with sub-attomolar sensitivity and single-base specificity
Abstract
CRISPR-based nucleic acid detection methods are reported to facilitate rapid and sensitive DNA detection. However, precise DNA detection at the single-base resolution and its wide applications including high-fidelity SNP genotyping remain to be explored. Here we develop a Cas12b-mediated DNA detection (CDetection) strategy, which shows higher sensitivity on examined targets compared with the previously reported Cas12a-based detection platform....
Paper Details
Title
CDetection: CRISPR-Cas12b-based DNA detection with sub-attomolar sensitivity and single-base specificity
Published Date
Jul 1, 2019
Journal
Volume
20
Issue
1
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