Abstract 1745: Ku70 suppresses alternative end-joining in G1-arrested progenitor B cells
Abstract
Classical non-homologous end-joining (C-NHEJ) repairs DNA double-stranded breaks (DSBs) throughout interphase but is thought to predominate in G1-phase when homologous recombination is unavailable. Complexes containing the Ku70/80 (Ku) and XRCC4/Ligase4 core C-NHEJ factors are required, respectively, for sensing and joining DSBs. While such factors are exclusively required for joining RAG-initiated DSBs during V(D)J recombination in G1-phase...
Paper Details
Title
Abstract 1745: Ku70 suppresses alternative end-joining in G1-arrested progenitor B cells
Published Date
Jul 1, 2019
Journal
Volume
79
Pages
1745 - 1745
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