Simultaneous determination of cardiovascular drugs in dried blood spot by liquid chromatography-tandem mass spectrometry
Abstract
A dried blood spot (DBS) sampling method was exploited to extract cardiovascular drugs using a small volume of whole blood of human and rodent. Thereafter, an analytical method using liquid chromatography with tandem mass spectrometry (LC-MS/MS) was developed and validated for the determination of 12 cardiovascular drugs. A 6 mm internal diameter disc containing 10 μL of blood was punched from a specifically designed card and analyzed by...
Paper Details
Title
Simultaneous determination of cardiovascular drugs in dried blood spot by liquid chromatography-tandem mass spectrometry
Published Date
Oct 1, 2019
Volume
27
Issue
4
Pages
906 - 914
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