Adding insult to injury: synergistic effect of combining risk-factors in models of post-traumatic osteoarthritis

“Synergy” is the interaction of two or more factors to produce a combined outcome greater than the sum of their individual effects. It is interesting to consider synergism in the context of osteoarthritis (OA) as a “whole-joint disease”, and how the combination of individual events or risk-factors that contribute to OA initiation and/or progression, may have more than just additive effects on joint-wide OA pathology and its systemic symptomatic...