Structural and functional consequences of the STAT5BN642H driver mutation
Abstract
Hyper-activated STAT5B variants are high value oncology targets for pharmacologic intervention. STAT5BN642H, a frequently-occurring oncogenic driver mutation, promotes aggressive T-cell leukemia/lymphoma in patient carriers, although the molecular origins remain unclear. Herein, we emphasize the aggressive nature of STAT5BN642H in driving T-cell neoplasia upon hematopoietic expression in transgenic mice, revealing evidence of multiple T-cell...
Paper Details
Title
Structural and functional consequences of the STAT5BN642H driver mutation
Published Date
Jun 7, 2019
Journal
Volume
10
Issue
1
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