Optimization of peptidic HIV‐1 fusion inhibitor T20 by phage display
Abstract
The HIV fusion inhibitor T20 has been approved to treat those living with HIV/AIDS, but treatment gives rise to resistant viruses. Using combinatorial phage-displayed libraries, we applied a saturation scan approach to dissect the entire T20 sequence for binding to a prefusogenic five-helix bundle (5HB) mimetic of HIV-1 gp41. Our data set compares all possible amino acid substitutions at all positions, and affords a complete view of the complex...
Paper Details
Title
Optimization of peptidic HIV‐1 fusion inhibitor T20 by phage display
Published Date
Jul 17, 2019
Journal
Volume
28
Issue
8
Pages
1501 - 1512
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