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Stranded on Antipsychotics: Role of the Pediatric Clinician

Published on Oct 1, 2019in Clinical Pediatrics1.383
路 DOI :10.1177/0009922819853774
Rachel Rushton Ballard (NU: Northwestern University), Nia Jenee Heard-Garris3
Estimated H-index: 3
(NU: Northwestern University)
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Abstract
  • References (16)
  • Citations (0)
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2015
1 Author (Juan Medrano)
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References16
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Background:Antipsychotic drug use in children has doubled from 2001 to 2007 with concomitant increase in obesity. Second-generation antipsychotic (SGA) medication use is associated with weight gain, metabolic derangements, and blood sugar and lipid abnormalities in children. The American Psychiatric
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#1Wayne A. Ray (Vandy: Vanderbilt University)H-Index: 78
#2C. Michael Stein (Vandy: Vanderbilt University)H-Index: 66
Last. William O. Cooper (Vandy: Vanderbilt University)H-Index: 39
view all 8 authors...
Importance Children and youths who are prescribed antipsychotic medications have multiple, potentially fatal, dose-related cardiovascular, metabolic, and other adverse events, but whether or not these medications are associated with an increased risk of death is unknown. Objective To compare the risk of unexpected death among children and youths who are beginning treatment with antipsychotic or control medications. Design, Setting, and Participants This retrospective cohort study was conducted f...
13 CitationsSource
#1Maren CarbonH-Index: 36
#2John M. KaneH-Index: 105
Last. Christoph U. CorrellH-Index: 61
view all 4 authors...
9 CitationsSource
#1Pierre EllulH-Index: 1
#2Richard Delorme (Pasteur Institute)H-Index: 42
Last. Samuele CorteseH-Index: 56
view all 3 authors...
Background Weight gain is a potentially concerning side effect of second-generation antipsychotics (SGAs). Metformin, a biguanide with antihyperglycemic effects, is used to manage weight gain in adults treated with SGAs.
4 CitationsSource
#1Jonathan D. Thackeray (OSU: Ohio State University)H-Index: 3
#2Dushka Crane (OSU: Ohio State University)H-Index: 3
Last. Mary Applegate (OSU: Ohio State University)H-Index: 1
view all 6 authors...
A Medicaid statewide quality improvement (QI) collaborative was developed to improve antipsychotic prescribing practices for children. With use of a multistrategy approach that incorporated data-dr...
3 CitationsSource
#1David Glesener (UMN: University of Minnesota)H-Index: 2
#2Gwendolyn D. Anderson (UMN: University of Minnesota)H-Index: 3
Last. Donald G. FergusonH-Index: 1
view all 7 authors...
Abstract Objective: This study assesses the effects of race, age, sex, and time spent in foster care on rates of psychotropic medication use for children in foster care in 2012. Methods: Using existing electronic records through county Social Service and Minnesota Medical Assistance databases, 626 children were identified using the inclusion criteria of having been in foster care for at least 30 days during 2012 in St. Louis County, Minnesota. All prescriptions for dispensed psychotropic medicat...
1 CitationsSource
#1Sinead Brophy (Swansea University)H-Index: 31
#2Jonathan Kennedy (Swansea University)H-Index: 4
Last. Michael Patrick Kerr (Cardiff University)H-Index: 35
view all 7 authors...
Abstract Objective: Antipsychotics are licensed for psychosis and are also prescribed for behavior control. This study aims to examine characteristics and outcomes of children prescribed antipsychotics. Methods: A cohort study using general practice and hospital records linked with education records for 1,488,936 children living in Wales between 1999 and 2015. The characteristics of the children who were prescribed antipsychotics are presented using descriptive statistics and outcomes such as re...
3 CitationsSource
#1Angel L. Montejo (University of Salamanca)H-Index: 24
#2Celso Arango (Hospital General Universitario Gregorio Mara帽贸n)H-Index: 53
Last. Eduard Vieta (University of Barcelona)H-Index: 96
view all 19 authors...
Hyperprolactinemia is an underappreciated/unknown adverse effects of antipsychotics. The consequences of hyperprolactinemia compromise therapeutic adherence and can be serious. We present the consensus recommendations made by a group of experts regarding the management of antipsychotic-induced hyperprolactinemia. The current consensus was developed in 3 phases: 1, review of the scientific literature; 2, subsequent round table discussion to attempt to reach a consensus among the experts; and 3, r...
12 CitationsSource
#1Minji SohnH-Index: 6
#2Daniela C. MogaH-Index: 9
Last. Jeffery C. TalbertH-Index: 14
view all 4 authors...
The objectives of the study were as follows: to examine the national trend of pediatric atypical antipsychotic (AAP) use in the United States; to identify primary mental disorders associated with AAPs; to estimate the strength of independent associations between patient/provider characteristics and AAP use. Data are from the National Ambulatory Medical Care Survey and the National Hospital Ambulatory Medical Care Survey. First, average AAP prescription rates among 4 and 18-year-old patients betw...
18 CitationsSource
#1Stephen Crystal (RU: Rutgers University)H-Index: 49
#2Thomas I. Mackie (RU: Rutgers University)H-Index: 7
Last. Scott Bilder (RU: Rutgers University)H-Index: 11
view all 7 authors...
The rapid growth of antipsychotic medication use among publicly insured children in the early and mid-2000s spurred new state efforts to monitor and improve prescription behavior. A starting point for many oversight initiatives was the foster care system, where most of the children are insured publicly through Medicaid. To understand the context and the effects of these initiatives, we analyzed patterns and trends in antipsychotic treatment of Medicaid-insured children in foster care and those i...
12 CitationsSource
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