IBRUTINIB DECREASES OBINUTUZUMAB-INDUCED SECRETION OF CYTOKINES ASSOCIATED WITH INFUSION-RELATED REACTIONS IN PATIENTS WITH CLL: ANALYSIS FROM THE ILLUMINATE STUDY

Introduction: Infusion-related reactions (IRRs) are potentially serious complications resulting from release of inflammatory cytokines in response to administration of certain drugs, including obinutuzumab (G), an anti-CD20 antibody (Freeman, Blood2015). In the phase 3 iLLUMINATE study of first-line ibrutinib-G (ibr-G) vs chlorambucil-G (clb-G) in patients (pts) with chronic lymphocytic leukemia (CLL), IRRs were decreased with ibr-G vs clb-G...