The alarmin S100A9 hampers osteoclast differentiation from human circulating precursors by reducing the expression of RANK

Volume: 33, Issue: 9, Pages: 10104 - 10115
Published: Jun 14, 2019
Abstract
The alarmin S100A8/A9 is implicated in sterile inflammation-induced bone resorption and has been shown to increase the bone-resorptive capacity of mature osteoclasts. Here, we investigated the effects of S100A9 on osteoclast differentiation from human CD14+ circulating precursors. Hereto, human CD14+ monocytes were isolated and differentiated toward osteoclasts with M-CSF and receptor activator of NF-κB (RANK) ligand (RANKL) in the presence or...
Paper Details
Title
The alarmin S100A9 hampers osteoclast differentiation from human circulating precursors by reducing the expression of RANK
Published Date
Jun 14, 2019
Volume
33
Issue
9
Pages
10104 - 10115
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