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Leucoencefalopatía posthipóxica diferida reversible.

Published on Jan 1, 2018in Neurologia 2.04
· DOI :10.1016/j.nrl.2015.11.011
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References12
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Published on May 31, 2014in Journal of Radiology Case Reports
Ana F. Geraldo2
Estimated H-index: 2
,
Cristiana Silva2
Estimated H-index: 2
+ 2 AuthorsLuísa Albuquerque7
Estimated H-index: 7
Delayed leukoencephalopathy is an uncommon complication of hypoxic-ischemic events of different etiologies, including carbon monoxide intoxication. We present a case of a 40-year-old male patient who was admitted with rapidly progressive neurocognitive and behavioral deficits. There was a history of accidental carbon monoxide intoxication one month before, presenting with loss of consciousness and short hospitalization, followed by a complete clinical recovery. The imaging studies in the delayed...
Published on Apr 1, 2013in Practical Neurology
Daniel Blackburn1
Estimated H-index: 1
(Royal Hallamshire Hospital),
James J.P. Alix10
Estimated H-index: 10
(Royal Hallamshire Hospital)
+ 2 AuthorsOliver Bandmann35
Estimated H-index: 35
(Royal Hallamshire Hospital)
The syndrome of delayed toxic–hypoxic encephalopathy is triggered by a sedating toxin that precipitates a period of cerebral hypoxaemia. The syndrome is rare and has a classic biphasic course with a seemingly complete recovery from the first episode of coma followed by a dramatic deterioration. We describe the diagnostic challenge provided by such a case. Day 1 : A 37-year-old man took 30 ml of methadone, 150 mg diazepam, plus cannabis and alcohol. On waking the next day, he took 20 ml more meth...
Published on Jan 1, 2012in Rinshō shinkeigaku Clinical neurology
Shiho Okuda10
Estimated H-index: 10
,
Masao Ueno2
Estimated H-index: 2
+ 3 AuthorsShin Takano2
Estimated H-index: 2
Published on Jan 1, 2010in NeuroRehabilitation 1.20
David Shprecher12
Estimated H-index: 12
,
Lahar Mehta1
Estimated H-index: 1
Delayed post-hypoxic leukoencephalopathy (DPHL) is a demyelinating syndrome characterized by acute onset of neuropsychiatric symptoms days to weeks following apparent recovery from coma after a period of prolonged cerebral hypo-oxygenation. It is diagnosed, after excluding other potential causes of delirium, with a clinical history of carbon monoxide poisoning, narcotic overdose, myocardial infarction, or another global cerebral hypoxic event. The diagnosis can be supported by neuroimaging evide...
Published on May 19, 2009in Neurology 8.69
Eduardo E. Benarroch54
Estimated H-index: 54
AMPA= : α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; ATP= : adenosine triphosphate; EAAT= : excitatory amino acid transporters; GABA= : γ-aminobutyric acid; GCI= : glial cytoplasmic inclusion; MS= : multiple sclerosis; MSA= : multiple system atrophy; NG2= : neuron glia 2; NO= : nitric oxide; NOS= : nitric oxide synthase; OPC= : oligodendrocyte progenitor cell; PDGF= : platelet-derived growth factor–α; PVL= : periventricular leukomalacia; TNF= : tumor necrosis factor. Oligodendrocytes ar...
Published on Jan 1, 2008in JAMA Neurology 12.32
Alice Chen-Plotkin38
Estimated H-index: 38
,
Kaipo T. Pau1
Estimated H-index: 1
,
Jeremy D. Schmahmann58
Estimated H-index: 58
A53-YEAR-OLD WOMAN wastransferredtoour institution from another country for evaluation of mutism, quadriparesis, and incontinence. She had undergone hysterectomy for menorrhagia, complicated byaneventcharacterizedtothefamily as the patient having “died” prior to resuscitation. She was reportedly comatose for 2 days but recovered well and functioned normally for 2 weeks.Shethenbecameconfused,developed gait difficulty and incontinence, and her condition deteriorated further over 2 weeks prior to
Published on Jan 1, 2006in American Journal of Neuroradiology 3.26
S. Molloy1
Estimated H-index: 1
,
Calvin Soh4
Estimated H-index: 4
,
T.L. Williams1
Estimated H-index: 1
SUMMARY: Hypoxic ischemic encephalopathy may cause early deep white matter abnormalities on MR imaging that usually progress to include gray matter and basal ganglia change. Toxic leukoencephalopathy due to heroin inhalation predominantly causes cerebellar and posterior cerebral radiologic change. Both conditions rarely present clinically and radiologically in a delayed manner with subsequent recovery. We report a case of reversible delayed posthypoxic/toxic leukoencephalopathy with no clinical ...
Published on Nov 1, 1997in Neurology 8.69
Jay A. Gottfried26
Estimated H-index: 26
(NYU: New York University),
Stephan A. Mayer68
Estimated H-index: 68
(Columbia University)
+ 2 AuthorsJ.H. Duyn8
Estimated H-index: 8
(NIH: National Institutes of Health)
Delayed demyelination is a rare and poorly understood complication of hypoxic brain injury. A previous case report has suggested an association with mild-to-moderate deficiency of arylsulfatase A. We describe a 36-year-old man who recovered completely from an episode of hypoxia related to drug overdose, and 2 weeks later progressed from a confusional state to deep coma. MRI showed diffuse white matter signal changes, and brain biopsy demonstrated a noninflammatory demyelinating process. Proton m...
Published on Jan 1, 1994in Neurology 8.69
L. M. Weinberger2
Estimated H-index: 2
,
James W. Schmidley11
Estimated H-index: 11
+ 1 AuthorsS. Raghavan1
Estimated H-index: 1
We report a patient with delayed postanoxic demyelination who had pseudodeficiency of arylsulfatase A, reducing his enzyme activity to 10 to 30% of normal. This may have implications regarding the pathogenesis of postanoxic demyelination.
Published on Jan 1, 1993in Internal Medicine 0.96
Tomohiko Mizutani22
Estimated H-index: 22
,
Ryoichi Shiozawa3
Estimated H-index: 3
+ 2 AuthorsHiroshi Akiyama20
Estimated H-index: 20
Delayed post-anoxic encephalopathy (DPE) not related to carbon monoxide has rarely been reported and usually carries a poor prognosis. We describe two surviving patients with such DPE and its neuro-otological characteristics. The DPE was caused by shock due to hemorrhage in a 21-year-old student, and by severe hypoxia and hypotension in a 60-year-old man. Our findings suggest that this type of DPEmight not be rare, if the patients who suffered from severe anoxia, marked hypotension or both are c...
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