FRI0510 THE EFFECT AND MECHANISM OF HUMAN UMBILICAL CORD MESENCHYMAL STEM CELLS-DERIVED EXOSOMES ON BONE DESTRUCTION OF COLLAGEN INDUCED ARTHRITIS RATS

Background null Rheumatoid arthritis (RA) is a highly disabling autoimmune disease, characterized by destruction of the cartilage and bone, which is difficult to reverse. mesenchymal stem cells-derived exosomes (Mesenchymal stem cells-derived Exos) is a kind of extracellular vesicle, produced by MSCs in resting or stress state, which can simulate the tissue repair effect of its maternal cells and may be a new breakthrough point in the treatment...