Interrogation of human hematopoiesis at single-cell and single-variant resolution
Abstract
Widespread linkage disequilibrium and incomplete annotation of cell-to-cell state variation represent substantial challenges to elucidating mechanisms of trait-associated genetic variation. Here we perform genetic fine-mapping for blood cell traits in the UK Biobank to identify putative causal variants. These variants are enriched in genes encoding proteins in trait-relevant biological pathways and in accessible chromatin of hematopoietic...
Paper Details
Title
Interrogation of human hematopoiesis at single-cell and single-variant resolution
Published Date
Mar 11, 2019
Journal
Volume
51
Issue
4
Pages
683 - 693
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Notes
History