Measuring gene–gene interaction using Kullback–Leibler divergence
Abstract
Genome‐wide association studies (GWAS) are used to investigate genetic variants contributing to complex traits. Despite discovering many loci, a large proportion of “missing” heritability remains unexplained. Gene–gene interactions may help explain some of this gap. Traditionally, gene–gene interactions have been evaluated using parametric statistical methods such as linear and logistic regression, with multifactor dimensionality reduction (MDR)...
Paper Details
Title
Measuring gene–gene interaction using Kullback–Leibler divergence
Published Date
Jun 17, 2019
Journal
Volume
83
Issue
6
Pages
405 - 417
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