Dose escalation and switching of biologics in ulcerative colitis: a systematic literature review in real-world evidence

Background: Biologics used to treat ulcerative colitis (UC) may lose their effect over time, requiring patients to undergo dose escalation or treatment switching, and systematic literature reviews of real-world evidence on these topics are lacking.Aim: To summarize the occurrence and outcomes of dose escalation and treatment switching in UC patients in real-world evidence.Methods: Studies were searched through MEDLINE, MEDLINE IN PROCESS, Embase...