Original paper

Mutational signatures of DNA mismatch repair deficiency in C. elegans and human cancers

Volume: 28, Issue: 5, Pages: 666 - 675
Published: Apr 10, 2018
Abstract
Throughout their lifetime, cells are subject to extrinsic and intrinsic mutational processes leaving behind characteristic signatures in the genome. DNA mismatch repair (MMR) deficiency leads to hypermutation and is found in different cancer types. Although it is possible to associate mutational signatures extracted from human cancers with possible mutational processes, the exact causation is often unknown. Here, we use C. elegans genome...
Paper Details
Title
Mutational signatures of DNA mismatch repair deficiency in C. elegans and human cancers
Published Date
Apr 10, 2018
Volume
28
Issue
5
Pages
666 - 675
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