Enhanced acetylation of ATP-citrate lyase promotes the progression of nonalcoholic fatty liver disease
Volume: 294, Issue: 31, Pages: 11805 - 11816
Published: Aug 1, 2019
Abstract
Hepatic steatosis is a hallmark of nonalcoholic fatty liver disease (NAFLD) and is promoted by dysregulated de novo lipogenesis. ATP-citrate lyase (ACLY) is a crucial lipogenic enzyme that is up-regulated in individuals with NAFLD. A previous study has shown that acetylation of ACLY at Lys-540, Lys-546, and Lys-554 (ACLY-3K) increases ACLY protein stability by antagonizing its ubiquitylation, thereby promoting lipid synthesis and cell...
Paper Details
Title
Enhanced acetylation of ATP-citrate lyase promotes the progression of nonalcoholic fatty liver disease
Published Date
Aug 1, 2019
Volume
294
Issue
31
Pages
11805 - 11816
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