Original paper
Linkage disequilibrium–dependent architecture of human complex traits shows action of negative selection
Abstract
Recent work has hinted at the linkage disequilibrium (LD)-dependent architecture of human complex traits, where SNPs with low levels of LD (LLD) have larger per-SNP heritability. Here we analyzed summary statistics from 56 complex traits (average N = 101,401) by extending stratified LD score regression to continuous annotations. We determined that SNPs with low LLD have significantly larger per-SNP heritability and that roughly half of this...
Paper Details
Title
Linkage disequilibrium–dependent architecture of human complex traits shows action of negative selection
Published Date
Sep 11, 2017
Journal
Volume
49
Issue
10
Pages
1421 - 1427
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Notes
History