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Evaluating diagnostic strategies for early detection of cancer: the CanTest framework

Published on Dec 1, 2019in BMC Cancer2.933
· DOI :10.1186/s12885-019-5746-6
Fiona M Walter34
Estimated H-index: 34
(University of Cambridge),
Matthew Thompson32
Estimated H-index: 32
(UW: University of Washington)
+ 12 AuthorsJon Emery42
Estimated H-index: 42
(University of Melbourne)
Abstract
Background Novel diagnostic triage and testing strategies to support early detection of cancer could improve clinical outcomes. Most apparently promising diagnostic tests ultimately fail because of inadequate performance in real-world, low prevalence populations such as primary care or general community populations. They should therefore be systematically evaluated before implementation to determine whether they lead to earlier detection, are cost-effective, and improve patient safety and quality of care, while minimising over-investigation and over-diagnosis.
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