Lycopene Protects Cortical Neurons via Oxidative Stress-mediated ΔN-Bcl-xL Formation (FS05-08-19)

Objectives B-cell lymphoma-extra large (Bcl-xL) is a protein found in the mitochondrial membrane with anti-apoptotic properties. Bcl-xL has demonstrated neuroprotective effects by enhancing mitochondrial function. However, during oxidative stress, Bcl-xL undergoes cleavage to form pro-cell death ∆N-Bcl-xL. Accumulation of ∆N-Bcl-xL causes abnormal mitochondrial channel activity associated with neuronal death. Therefore, strategies that prevent...