OSCA: a tool for omic-data-based complex trait analysis.
Abstract
The rapid increase of omic data has greatly facilitated the investigation of associations between omic profiles such as DNA methylation (DNAm) and complex traits in large cohorts. Here, we propose a mixed-linear-model-based method called MOMENT that tests for association between a DNAm probe and trait with all other distal probes fitted in multiple random-effect components to account for unobserved confounders. We demonstrate by simulations that...
Paper Details
Title
OSCA: a tool for omic-data-based complex trait analysis.
Published Date
May 28, 2019
Journal
Volume
20
Issue
1
Pages
107
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