Mitochondrial Na+ import controls oxidative phosphorylation and hypoxic redox signaling

Volume: 120
Published: May 20, 2018
Abstract
All metazoans depend on O2 delivery and consumption by the mitochondrial oxidative phosphorylation (OXPHOS) system to produce energy. A decrease in O2 availability (hypoxia) leads to profound metabolic rewiring. In addition, OXPHOS uses O2 to produce reactive oxygen species (ROS) that can drive cell adaptations through redox signalling, but also trigger cell damage1–4, and both phenomena occur in hypoxia4–8. However, the precise mechanism by...
Paper Details
Title
Mitochondrial Na+ import controls oxidative phosphorylation and hypoxic redox signaling
Published Date
May 20, 2018
Volume
120
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