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LLIN Evaluation in Uganda Project (LLINEUP): factors associated with childhood parasitaemia and anaemia 3 years after a national long-lasting insecticidal net distribution campaign: a cross-sectional survey

Published on Dec 1, 2019in Malaria Journal2.798
· DOI :10.1186/s12936-019-2838-3
Sheila Rugnao1
Estimated H-index: 1
(UCSF: University of California, San Francisco),
Samuel Gonahasa4
Estimated H-index: 4
+ 10 AuthorsSarah G. Staedke39
Estimated H-index: 39
(Lond: University of London)
Abstract
Background Recent reductions in malaria burden have been attributed largely to long-lasting insecticidal nets (LLINs). In March–June 2017, approximately 3 years after a national LLIN distribution campaign, a cross-sectional community survey was conducted to investigate factors associated with malaria parasitaemia and anaemia, in advance of Uganda’s 2017–2018 LLIN campaign.
  • References (69)
  • Citations (1)
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References69
Newest
#1Sarah G. Staedke (Lond: University of London)H-Index: 39
#2Moses R. Kamya (MUK: Makerere University)H-Index: 53
Last. Martin J. Donnelly (LSTM: Liverpool School of Tropical Medicine)H-Index: 40
view all 10 authors...
Long-lasting insecticidal nets (LLINs) are a key malaria control intervention, but their effectiveness is threatened by resistance to pyrethroid insecticides. Some new LLINs combine pyrethroids with piperonyl butoxide (PBO), a synergist that can overcome P450-based metabolic resistance to pyrethroids in mosquitoes. In 2017–2018, the Ugandan Ministry of Health distributed LLINs with and without PBO through a national mass-distribution campaign, providing a unique opportunity to rigorously evaluat...
1 CitationsSource
#1Joaniter Nankabirwa (MUK: Makerere University)H-Index: 15
#2Jessica Briggs (UCSF: University of California, San Francisco)H-Index: 3
Last. Bryan Greenhouse (UCSF: University of California, San Francisco)H-Index: 33
view all 12 authors...
Background:Indoor residual spraying of insecticide (IRS) has been associated with reductions in the incidence of malaria, but its impact on malaria parasitemia is unclear. Methods:We followed 469 participants from August 2011 to May 2016 in Tororo, Uganda, a historically high malaria transmission setting. Three rounds of IRS with bendiocarb were implemented from December 2014 to December 2015. Symptomatic malaria episodes were identified by passive surveillance. Parasitemia was identified by act...
3 CitationsSource
#1Amy Lynd (LSTM: Liverpool School of Tropical Medicine)H-Index: 11
#2Samuel GonahasaH-Index: 4
Last. Martin J. Donnelly (LSTM: Liverpool School of Tropical Medicine)H-Index: 40
view all 13 authors...
Background Long-lasting insecticidal nets (LLINs) are the principal tool for malaria control in Africa and are presently treated with a single class of insecticide; however, increasing levels of insecticide resistance threaten their success. In response to this threat nets have been developed that incorporate the synergist, piperonyl butoxide (PBO), which inhibits the activity of cytochrome P450s which is one main mechanisms of insecticide resistance, allowing resistance to pyrethroids to be rev...
1 CitationsSource
#1Samuel GonahasaH-Index: 4
Last. Sarah G. Staedke (Lond: University of London)H-Index: 39
view all 13 authors...
Long-lasting insecticidal nets (LLINs) are a key malaria control intervention. To investigate factors associated with ownership and use of LLINs in Uganda, a cross-sectional community survey was conducted in March–June 2017, approximately 3 years after a national Universal Coverage Campaign (UCC). Households from 104 clusters (health sub-districts) in 48 districts were randomly selected using two-staged cluster sampling; 50 households were enrolled per cluster. Outcomes were household ownership ...
5 CitationsSource
#1Isabel Rodriguez-Barraquer (UCSF: University of California, San Francisco)H-Index: 17
#2Emmanuel ArinaitweH-Index: 19
Last. Bryan Greenhouse (UCSF: University of California, San Francisco)H-Index: 33
view all 14 authors...
Malaria kills around 500,000 children every year. The disease occurs when an infected mosquito bites a human and passes on a Plasmodium parasite. One parasite in particular, Plasmodium falciparum, is responsible for most malaria-related deaths across the globe. A person can be infected by P. falciparum many times throughout their life. However, after children have had multiple infections, they become less likely to develop symptoms of malaria, such as high fever. In other words, they gradually a...
13 CitationsSource
#1Su Yun Kang (University of Oxford)H-Index: 5
#2Katherine E. Battle (University of Oxford)H-Index: 25
Last. Donal Bisanzio (RTI International)H-Index: 30
view all 13 authors...
Background: Heterogeneity in malaria transmission has household, temporal, and spatial components. These factors are relevant for improving the efficiency of malaria control by targeting heterogeneity. To quantify variation, we analyzed mosquito counts from entomological surveillance conducted at three study sites in Uganda that varied in malaria transmission intensity. Mosquito biting or exposure is a risk factor for malaria transmission. Methods: Using a Bayesian zero-inflated negative binomia...
5 CitationsSource
#1Florian Girond (Pasteur Institute)H-Index: 3
#2Yoann Madec (Pasteur Institute)H-Index: 24
Last. Patrice Piola (Pasteur Institute)H-Index: 20
view all 12 authors...
Abstract Background The reduction of global malaria burden over the past 15 years is much attributed to the expansion of mass distribution campaigns (MDCs) of long-lasting insecticidal nets (LLIN). In Madagascar, two LLIN MDCs were implemented and one district also benefited from a community-based continuous distribution (CB-CD). Malaria incidence dropped but eventually rebounded after a decade. Methods Data from a sentinel surveillance network over the 2009–2015 period was analyzed. Alerts were...
3 CitationsSource
#1Sarah G. Staedke (Lond: University of London)H-Index: 39
Last. Chris Drakeley (Lond: University of London)H-Index: 73
view all 11 authors...
Summary Background Intermittent preventive treatment (IPT) is a well established malaria control intervention. Evidence that delivering IPT to schoolchildren could provide community-level benefits is limited. We did a cluster-randomised controlled trial to assess the effect of IPT of primary schoolchildren with dihydroartemisinin-piperaquine (DP) on indicators of malaria transmission in the community, in Jinja, Uganda. Methods We included 84 clusters, each comprising one primary school and the 1...
6 CitationsSource
#1Salomon G. Massoda Tonye (University of Basel)H-Index: 1
#2Celestin KouambengH-Index: 3
Last. Penelope Vounatsou (University of Basel)H-Index: 55
view all 4 authors...
In 2011, the demographic and health survey (DHS) in Cameroon was combined with the multiple indicator cluster survey. Malaria parasitological data were collected, but the survey period did not overlap with the high malaria transmission season. A malaria indicator survey (MIS) was also conducted during the same year, within the malaria peak transmission season. This study compares estimates of the geographical distribution of malaria parasite risk and of the effects of interventions obtained from...
3 CitationsSource
#1John Rek (Mulago Hospital)H-Index: 10
#2Victor A. Alegana (University of Southampton)H-Index: 20
Last. Lucy S. Tusting (University of Oxford)H-Index: 14
view all 12 authors...
Summary Background Rapid population growth in Africa requires an urgent expansion and improvement of housing options. Improving housing presents a promising opportunity for malaria control by reducing indoor exposure to mosquitoes. We measured recent changes in house design in rural Uganda and evaluated their association with malaria in relation to a mass scale-up of control efforts. Methods This analysis was part of a cohort study designed to compare temporal changes in malaria incidence from a...
13 CitationsSource
Cited By1
Newest
#1Sarah G. Staedke (Lond: University of London)H-Index: 39
#2Samuel GonahasaH-Index: 4
Last. Simon P. KigoziH-Index: 6
view all 13 authors...
Summary Background Long-lasting insecticidal nets (LLINs) are the primary malaria prevention tool, but their effectiveness is threatened by pyrethroid resistance. We embedded a pragmatic cluster-randomised trial into Uganda's national LLIN campaign to compare conventional LLINs with those containing piperonyl butoxide (PBO), a synergist that can partially restore pyrethroid susceptibility in mosquito vectors. Methods 104 health sub-districts, from 48 districts in Uganda, were randomly assigned t...
1 CitationsSource
#1Andrea M. Rehman (Lond: University of London)H-Index: 14
Last. Sarah G. Staedke (Lond: University of London)H-Index: 39
view all 10 authors...
Intermittent preventive treatment (IPT) of malaria is recommended as policy for certain high-risk populations, but not currently for schoolchildren. A cluster-randomized trial was conducted to evaluate the effect of IPT with dihydroartemisinin–piperaquine (DP) on primary schoolchildren in Jinja, Uganda. Results of the impact of IPT of schoolchildren on community-level transmission have been reported previously. Here, secondary outcomes from a school-based survey are presented. Eighty-four cluste...
Source