Chemotherapy weakly contributes to predicted neoantigen expression in ovarian cancer
Abstract
Patients with highly mutated tumors, such as melanoma or smoking-related lung cancer, have higher rates of response to immune checkpoint blockade therapy, perhaps due to increased neoantigen expression. Many chemotherapies including platinum compounds are known to be mutagenic, but the impact of standard treatment protocols on mutational burden and resulting neoantigen expression in most human cancers is unknown.We sought to quantify the effect...
Paper Details
Title
Chemotherapy weakly contributes to predicted neoantigen expression in ovarian cancer
Published Date
Jan 22, 2018
Journal
Volume
18
Issue
1
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