Reduced subcutaneous adipogenesis in human hypertrophic obesity is linked to senescent precursor cells
Abstract
Inappropriate expansion of the adipose cells in the subcutaneous adipose tissue (SAT) is a characteristic of hypertrophic obesity and of individuals with genetic predisposition for T2D (first-degree relatives; FDR). It is associated with insulin resistance, a dysfunctional, adipose tissue and reduced adipogenesis. We examined the regulation of adipogenesis in human SAT precursor cells and found ZNF521 to be a critical regulator of early...
Paper Details
Title
Reduced subcutaneous adipogenesis in human hypertrophic obesity is linked to senescent precursor cells
Published Date
Jun 21, 2019
Journal
Volume
10
Issue
1
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