Inhibition of DNA2 nuclease as a therapeutic strategy targeting replication stress in cancer cells
Abstract
Replication stress is a characteristic feature of cancer cells, which is resulted from sustained proliferative signaling induced by activation of oncogenes or loss of tumor suppressors. In cancer cells, oncogene-induced replication stress manifests as replication-associated lesions, predominantly double-strand DNA breaks (DSBs). An essential mechanism utilized by cells to repair replication-associated DSBs is homologous recombination (HR). In...
Paper Details
Title
Inhibition of DNA2 nuclease as a therapeutic strategy targeting replication stress in cancer cells
Published Date
Apr 17, 2017
Journal
Volume
6
Issue
4
Pages
e319 - e319
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