Genome-wide quantification of the effects of DNA methylation on human gene regulation
Abstract
Changes in DNA methylation are involved in development, disease, and the response to environmental conditions. However, not all regulatory elements are functionally methylation-dependent (MD). Here, we report a method, mSTARR-seq, that assesses the causal effects of DNA methylation on regulatory activity at hundreds of thousands of fragments (millions of CpG sites) simultaneously. Using mSTARR-seq, we identify thousands of MD regulatory elements...
Paper Details
Title
Genome-wide quantification of the effects of DNA methylation on human gene regulation
Published Date
Dec 21, 2018
Journal
Volume
7
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