PF756 DONOR UNC-93 HOMOLOG B1 GENETIC VARIATION PREDICTS SURVIVAL OUTCOMES AFTER UNRELATED BONE MARROW TRANSPLANTATION

Background: The toll-like receptors (TLRs) are the most important pattern recognition receptors that sense invading pathogens and mount innate and adaptive immune response. TLRs are also suggested to contribute to the inflammatory process after allogeneic stem cell transplantation (allo-SCT). Unc-93 homolog B1 (UNC93B1) is a key regulator of TLRs and delivers them from the endoplasmic reticulum to their respective endosomal signaling...