Alterations in Organismal Physiology, Impaired Stress Resistance, and Accelerated Aging inDrosophilaFlies Adapted to Multigenerational Proteome Instability

Being an assembly of highly sophisticated protein machines, cells depend heavily on proteostatic modules functionality and on adequate supply of energetic molecules for maintaining proteome stability. Yet, our understanding of the adaptations induced by multigenerational proteotoxic stress is limited. We report here that multigenerational (>80 generations) proteotoxic stress in Oregon R flies induced by constant exposure to developmentally...