ATR is a multifunctional regulator of male mouse meiosis
Abstract
Meiotic cells undergo genetic exchange between homologs through programmed DNA double-strand break (DSB) formation, recombination and synapsis. In mice, the DNA damage-regulated phosphatidylinositol-3-kinase-like kinase (PIKK) ATM regulates all of these processes. However, the meiotic functions of the PIKK ATR have remained elusive, because germline-specific depletion of this kinase is challenging. Here we uncover roles for ATR in male mouse...
Paper Details
Title
ATR is a multifunctional regulator of male mouse meiosis
Published Date
Jul 5, 2018
Journal
Volume
9
Issue
1
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