Stabilization of Intrinsically Disordered DKK2 Protein by Fusion to RNA-Binding Domain

Volume: 20, Issue: 11, Pages: 2847 - 2847
Published: Jun 11, 2019
Abstract
Intrinsic disorders are a common feature of hub proteins in eukaryotic interactomes controlling the signaling pathways. The intrinsically disordered proteins (IDPs) are prone to misfolding, and maintaining their functional stability remains a major challenge in validating their therapeutic potentials. Considering that IDPs are highly enriched in RNA-binding proteins (RBPs), here we reasoned and confirmed that IDPs could be stabilized by fusion...
Paper Details
Title
Stabilization of Intrinsically Disordered DKK2 Protein by Fusion to RNA-Binding Domain
Published Date
Jun 11, 2019
Volume
20
Issue
11
Pages
2847 - 2847
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