Deconvolution of subcellular protrusion heterogeneity and the underlying actin regulator dynamics from live cell imaging
Abstract
Cell protrusion is morphodynamically heterogeneous at the subcellular level. However, the mechanism of cell protrusion has been understood based on the ensemble average of actin regulator dynamics. Here, we establish a computational framework called HACKS (deconvolution of heterogeneous activity in coordination of cytoskeleton at the subcellular level) to deconvolve the subcellular heterogeneity of lamellipodial protrusion from live cell...
Paper Details
Title
Deconvolution of subcellular protrusion heterogeneity and the underlying actin regulator dynamics from live cell imaging
Published Date
Apr 27, 2018
Journal
Volume
9
Issue
1
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