Molecular cloning, functional characterization and nutritional regulation of two elovl4b elongases from rainbow trout (Oncorhynchus mykiss)

Elongation of very long-chain fatty acids 4 (Elovl4) is a critical enzyme in the biosynthesis of long-chain and very long-chain polyunsaturated fatty acids (LC- and VLC-PUFAs) in animals. So far, very little is known about the molecular function of Elovl4 in biosynthetic process, especially in fish. In this study, two null elovl4 null paralogs ( elovl4b1 null and null elovl4b2 ) were successfully cloned from rainbow trout ( Oncorhynchus mykiss...