CRISPR-Cas9 interrogation of a putative fetal globin repressor in human erythroid cells

Volume: 14, Issue: 1, Pages: e0208237 - e0208237
Published: Jan 15, 2019
Abstract
Sickle Cell Disease and ß-thalassemia, which are caused by defective or deficient adult ß-globin (HBB) respectively, are the most common serious genetic blood diseases in the world. Persistent expression of the fetal ß-like globin, also known as 훾-globin, can ameliorate both disorders by serving in place of the adult ß-globin as a part of the fetal hemoglobin tetramer (HbF). Here we use CRISPR-Cas9 gene editing to explore a potential 훾-globin...
Paper Details
Title
CRISPR-Cas9 interrogation of a putative fetal globin repressor in human erythroid cells
Published Date
Jan 15, 2019
Journal
Volume
14
Issue
1
Pages
e0208237 - e0208237
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