Direct Observation of Topoisomerase IA Gate Dynamics

Volume: 25, Issue: 12, Pages: 1111 - 1118
Published: Nov 26, 2018
Abstract
Type IA topoisomerases cleave single-stranded DNA and relieve negative supercoils in discrete steps corresponding to the passage of the intact DNA strand through the cleaved strand. Although type IA topoisomerases are assumed to accomplish this strand passage via a protein-mediated DNA gate, opening of this gate has never been observed. We developed a single-molecule assay to directly measure gate opening of the Escherichia coli type IA...
Paper Details
Title
Direct Observation of Topoisomerase IA Gate Dynamics
Published Date
Nov 26, 2018
Volume
25
Issue
12
Pages
1111 - 1118
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